N OF 1
Film poster for "N of 1". An elderly man writes formulas on a window.
N OF 1
Film poster for "N of 1". An elderly man writes formulas on a window.
It’s Just an Idea Until the First Patient Takes A Chance

N OF 1

Regular price $129.00
/

Harvard Medical School Center for Bioethics | International Museum of Surgical Science | F. Hoffmann - La Roche, Basel, CH & Genentech | Dana-Farber Cancer Institute | The Mayo Clinic Dolores Jean Lavins Center for Humanities in Medicine

Medical Innovation • Clinical Ethics • Individual Courage • Cancer Research • Family • Connections • Hope, Innovation, Heartbreak & Inspiration


Date of Completion: 2023 | Run Time: 97 minutes​​ | Language: English Captions: Yes | Includes: Transcript & Study Guide | Director: Bernard Friedman | Executive Producers: Matthew Moul & Mark Lipson | Producer: Bernard Friedman | Editor: Matthew Moul | Cinematographer: Alphonse Roy 

Sometimes, in medicine, innovation can come from unexpected sources. N OF 1 follows a striking mix of characters on an international journey to save the life of Kayte, a 26-year-old from Alabama, whose doctors had run out of options for treating her rare, highly lethal liver cancer. Via a Facebook group for the few people in the world sharing her diagnosis, Kayte connects with Howard, a Canadian electronics businessman with no medical training, who has doubled in his spare time as a patient advocate, often scouring medical journals to understand cancer better to help patients like her. Howard recruits for Kayte a pioneering immunologist from Israel and renowned transplant surgeon from England to travel to India, where Kayte will undergo a first-of-its-kind procedure to save her life, and possibly dramatically advance traditional cancer treatment as we know it. This experimental treatment, a partial bone marrow transplant followed by a live liver transplant, may have pushed the regulatory boundaries of evidence-based medicine. But when you’re an N OF 1 — a singular patient, dying from a very rare and little researched disease — in the words of Kayte, to get to a cure,“someone has to be the first to say ‘I’ll try it.'"

The Jewish Light | Cate Marquis
"This emotionally charged documentary is both thought-provoking and inspirational, taking you on a journey spanning five countries, as 26-year-old Kayte, with the support of her family, bravely undergoes an unproven procedure, providing hope for a cure that will enable her to return home and help innumerable others as well." ,- Shari Clare,Cinequest"The documentary brings us close to all the people involved, Hollingsworth’s family, Simons and the two surgeons particularly. It also offers insights on medical research and the barriers in medicine to such new procedures, explained well by Dr. Ephraim Fuchs of Johns Hopkins. This involving documentary is both emotionally moving and informative."